Regulates hormone & sebum production
- A study shows a significant reduction of Sebum Excretion Rate (SER) in acne patients administered with erythromycin-zinc complex after 6 weeks. [1]
- Multiples studies show that adequate magnesium levels contribute to optimizing insulin sensitivity and stabilizing glucose metabolism. [2]
Soothe inflammation & redness
- 79% out of 198 acne patients reported significant reduction of inflammatory lesions after 4 weeks of oral administration of nicotinamide and zinc. [3]
- Administration of selenium to acne patients for eight weeks resulted in significant reduction of serum IL-8 levels.[4]
- 88% out of 235 the patients experienced a visible reduction in inflammatory lesions after 8 weeks of supplementation with nicotinamide,zinc, pyridoxine and copper. [5]
Reduces acne & breakouts
- Clinical improvement in 80% out of 300 acne patients after 5 weeks oral administration of Lactobacillus acidophilus blend. [6]
- A study shows that oral administration of Pantothenic Acid (Vitamin B5) to 41 acne patients reduces the number of total facial lesions by 67% in 12 weeks. [7]
- Piérard-Franchimont, Claudine, et al. "A Double-Blind Controlled Evaluation of the Sebosuppressive Activity of Topical Erythromycin-Zinc Complex." European Journal of Clinical Pharmacology, vol. 49, no. 1–2, 1995, pp. 57–60.
- Sousa Melo, Stéfany Rodrigues, et al. "Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review." Biological Trace Element Research, vol. 200, no. 8, 2022, pp. 3545–3553.
- Niren, Neil M., and Helen M. Torok. "The Nicomide Improvement in Clinical Outcomes Study (NICOS): Results of an 8-Week Trial." Cutis, vol. 77, no. 1 Suppl, 2006, pp. 17–28.
- Salekzamani, Elham, et al. "Effects of Silymarin, N-Acetylcysteine, and Selenium in the Treatment of Papulopustular Acne." Open Access Macedonian Journal of Medical Sciences, 2018, pp. 1–6.
- Shalita, Alan R., et al. "Inflammatory Acne Management with a Novel Prescription Dietary Supplement." Journal of Drugs in Dermatology, vol. 11, no. 12, 2012, pp. 1428–1433.
- Sánchez-Pellicer, Pedro, et al. "Acne, Microbiome, and Probiotics: The Gut–Skin Axis." Microorganisms, vol. 10, no. 7, 2022, article 1303.
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Yang, Michael, et al. "A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne." Dermatology and Therapy, vol. 4, no. 1, 2014, pp. 93–101.