Regulates hormone & sebum production
  • A study shows a significant reduction of Sebum Excretion Rate (SER) in acne patients administered with erythromycin-zinc complex after 6 weeks. [1]
  • Multiples studies show that adequate magnesium levels contribute to optimizing insulin sensitivity and stabilizing glucose metabolism. [2]
Soothe inflammation & redness
  • 79% out of 198 acne patients reported significant reduction of inflammatory lesions after 4 weeks of oral administration of nicotinamide and zinc. [3]
  • Administration of selenium to acne patients for eight weeks resulted in significant reduction of serum IL-8 levels.[4]
  • 88% out of 235 the patients experienced a visible reduction in inflammatory lesions after 8 weeks of supplementation with nicotinamide,zinc, pyridoxine and copper. [5]
    Reduces acne & breakouts
    • Clinical improvement in 80% out of 300 acne patients after 5 weeks oral administration of Lactobacillus acidophilus blend. [6]
    • A study shows that oral administration of Pantothenic Acid (Vitamin B5) to 41 acne patients reduces the number of total facial lesions by 67% in 12 weeks. [7]

    1. Piérard-Franchimont, Claudine, et al. "A Double-Blind Controlled Evaluation of the Sebosuppressive Activity of Topical Erythromycin-Zinc Complex." European Journal of Clinical Pharmacology, vol. 49, no. 1–2, 1995, pp. 57–60.
    2. Sousa Melo, Stéfany Rodrigues, et al. "Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review." Biological Trace Element Research, vol. 200, no. 8, 2022, pp. 3545–3553.
    3. Niren, Neil M., and Helen M. Torok. "The Nicomide Improvement in Clinical Outcomes Study (NICOS): Results of an 8-Week Trial." Cutis, vol. 77, no. 1 Suppl, 2006, pp. 17–28.
    4. Salekzamani, Elham, et al. "Effects of Silymarin, N-Acetylcysteine, and Selenium in the Treatment of Papulopustular Acne." Open Access Macedonian Journal of Medical Sciences, 2018, pp. 1–6.
    5. Shalita, Alan R., et al. "Inflammatory Acne Management with a Novel Prescription Dietary Supplement." Journal of Drugs in Dermatology, vol. 11, no. 12, 2012, pp. 1428–1433.
    6. Sánchez-Pellicer, Pedro, et al. "Acne, Microbiome, and Probiotics: The Gut–Skin Axis." Microorganisms, vol. 10, no. 7, 2022, article 1303.
    7. Yang, Michael, et al. "A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne." Dermatology and Therapy, vol. 4, no. 1, 2014, pp. 93–101.